This may seem like an odd thing for someone heavily invested in technology, as I am, to hate, but one of the things I absolutely, viscerally hate is the computer animation of animals (and babies) so as to give them the mannerisms and/or the speech of human adults.
It's a popular technique (this summer's Underdog, for example) and one that seems to appeal to plenty of people, but I find it deeply repulsive. I can't watch commercials that use it, and I won't watch it in movies.
When it's used for aliens, or fantasy creatures (Narnia, e.g.), it doesn't bother me at all. The talking toys and creatures in Wonderfalls? No problem. But a talking squirrel, or a dog raising its eyebrow, or babies turned into adults? That stuff makes me nauseous. (Yes, the dancing baby put me off Ally McBeal for the rest of that series' life.) I have a similar reaction to child beauty pageants, which made it difficult for me to watch/appreciate Little Miss Sunshine at the end.
There are plenty of things I don't care for, and just don't engage with, but the unnaturalness of this kind of anthropomorphism, for some reason, repulses me.